A new study published in Pharmacotherapy has shed light on some of the most potentially dangerous drugs for kidneys which, oddly enough, haven’t been recognized for their nephrotoxicity but are still observed to cause acute kidney injury.
Researchers quantified associations between medications and acute kidney injuries, categorizing them as either known, possible or new nephrotoxins. The 20 most frequently reported new potential nephrotxins which may be responsible for causing acute kidney injuries included:
- Aprotinin (brand name: Trasylol) Used to minimize bleeding
- Metformin (brands: Glumetza, Glucophage, Fortamet, Riomet, and Glucophage XR) Used for diabetes
- Zoledronic Acid (brand: Reclast) Used to treat bone damage.
- Lenalidomide (brand: Revlimid) Used to treat multiple myeloma.
- Dabigatran (brand: Pradaxa) Used as a blood thinner.
- Deferasirox (brands: Exjade, Jadenu, Jadenu Sprinkle) Used to treat iron toxicity.
- Adalimumab (brands: Humira Pen, Humira Pen Crohn’s-UC-HS Start, Humira Pediatric Crohn’s Start) Used to treat arthritis, plaque psoriasis, ankylosing spondylitis, Crohn’s disease, and ulcerative colitis.
- Atorvastatin (brand: Lipitor) Used to treat high cholesterol.
- Alendronate (brand: Fosamax, Binosto, and Fosamax Plus D) Used to treat/prevent osteoporosis.
- Everolimus (brands: Zortress, Afinitor, Afinitor Disperz) Used to treat certain cancers.
- Etanercept (brand: Enbrel) Used to treat autoimmune diseases.
- Digoxin (brands: Lanoxin, Digox, Lanoxin Pediatric) Used to treat heart rhythm disorders.
- Sunitinib (brand: Sutent) used to treat cancers.
- Exenatide (brands: Bydureon, Byetta) Used in diabetes.
- Bevacizumab (brand: Avastin) Used to treat certain cancers.
- Telaprevir (brands: Incivek, Incivo) Used to treat hepatitis.
- Rosuvastatin (brand: Crestor) Used to treat high cholesterol.
- Bortezomib (brand: Velcade) Used to treat certain cancers.
- Imatinib (brand: Gleevec) Used to treat leukemia.
- Aliskiren (brand: Tekturna) Used to treat high blood pressure.
Of course, there is still more research to be done and you should never stop taking a medication without your physician’s consent, but it’s always important to be mindful of the risks presented by prescriptions. Although a drug may be able to help address one set of symptoms, the risks may outweigh the benefits and being informed of this is vital to maintaining your best kidney health!