Constipation Related To CKD Could Cause Lasting Damage If Untreated

New research has shown constipation has been associated with the creating of uremic toxin p-cresylsulfate in patients suffering the chronic kidney disease. Results, however, did not show the same
condition of constipation with indoxyl sulfate. The kidneys are the filters of the blood and remove toxins and waste, allowing them to be expelled in urine. Those who lose part of their kidney function or all of it for an extended period of time suffer from chronic kidney disease (CKD).

The research was conducted by Christiane Ishikawa Ramos, PhD, of the Universidade Federal de Sao Paul in Brazil, and colleagues. They warned that constipation can lead to problems for those with
CKD. Patients can experience terrible damage to their gut dysbiosis, cardiovascular system and further damage to their renal system.

Researchers looked at 43 patients with CKD, but not diabetes. Diabetes can actually cause kidney problems as well. Researchers looked at the bowel habits referencing the Bristol Stool Scale and a questionnaire examining constipation related symptoms. Results showed constipation associated with a higher serum total PCS and higher urinary PCS. They noted while constipation could be treated and reduced, no one was making adjustments to their diet.

One reason may have been because the most common treatment is taking in more fluids and fiber. This is not realistic for CKD patients because increasing fiber and fluid can cause potassium and fluid overload.

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