Scientists have some new research regarding bisphenol A and phthalate exposure and association with kidney function in children. The study looked at the impact of repeated exposures to bisphenol A (BPA and phthalates with regards to their effects on kidney function, tubular injury and oxidative stress on children with chronic kidney disease.
Between 2005 and 2015, 618 children and teenagers were enrolled in the Chronic Kidney Disease in Children study. 63.8% of participants were male, 58.3% were white and the median age of participants was 11 years old. Urine samples were collected over 3 years and researchers looked for concentrations of BPA, phthalic acid (PA), and phthalate metabolites were measured as well as biomarkers of tubular injury (kidney injury molecule-1 [KIM-1] and neutrophil gelatinase-associated lipocalin [NGAL]) and oxidative stress (8-hydroxy-2′-deoxyguanosine [8-OHdG] and F2-isoprostane).
Additionally, they measured estimated glomerular filtration rate (eGFR), proteinuria, and blood pressure. Researchers found a pattern of increased tubular injury and oxidative stress over time in the patients. This damage has been shown to greatly impact the function of kidneys over the long term. For more of the latest research on kidney related studies be sure to check us out on YouTube for daily content!